Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer.

<h4>Background</h4>Differentially methylated regions (DMRs) are associated with many imprinted genes. In mice methylation at a DMR upstream of the H19 gene known as the Imprint Control region (IC1) is acquired in the male germline and influences the methylation status of DMRs 100 kb away...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Adele Murrell, Yoko Ito, Gaetano Verde, Joanna Huddleston, Kathryn Woodfine, Margherita Cirillo Silengo, Filippo Spreafico, Daniela Perotti, Agostina De Crescenzo, Angela Sparago, Flavia Cerrato, Andrea Riccio
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-03-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001849&type=printable