Heterogeneous Tau Oligomers as Molecular Targets for Alzheimer’s Disease and Related Tauopathies

Tauopathies, including Alzheimer’s disease (AD), are a group of neurodegenerative disorders characterized by pathological aggregation of microtubule binding protein tau. The presence of tau neurofibrillary tangles, which are insoluble β-sheet fibrils, in the brain has been the histopathological hall...

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Bibliographic Details

Published in:	Biophysica
Main Author:	Chih Hung Lo
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	tau oligomers and aggregates cellular and pathological heterogeneity neurotoxicity conformational ensembles protein-protein interaction molecular diversity
Online Access:	https://www.mdpi.com/2673-4125/2/4/39