Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage

IntroductionMesenchymal stromal cells (MSCs) have been evaluated as a local therapeutic option to treat osteoarthritis (OA) with conflicting clinical results. Our previous studies have evaluated immune licensing of MSC through activation of Toll-like receptor and cytosolic cGAS-STING pathways, with...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Peter Linde, Lyndah Chow, Isabella Sabino, Zoë Williams, Renata Impastato, Steven Dow, Lynn Pezzanite
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	osteoarthritis mesenchymal stromal cell regenerative therapies STING toll-like receptor pattern recognition receptor
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1605148/full