Quantification of residual plasmid DNA and SV40 promoter-enhancer sequences in Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada

For some of the COVID-19 vaccines, the drug substances released to market were manufactured differently than those used in clinical trials. Manufacturing nucleoside-modified mRNA (modRNA) for commercial COVID-19 vaccines relies on RNA polymerase transcription of a plasmid DNA template. Previous stud...

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Bibliographic Details
Published in:Autoimmunity
Main Authors: David J. Speicher, Jessica Rose, Kevin McKernan
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Subjects:
COVID-19
vaccine
modRNA
mRNA
residual DNA
DNA contamination
Online Access:https://www.tandfonline.com/doi/10.1080/08916934.2025.2551517

Internet

https://www.tandfonline.com/doi/10.1080/08916934.2025.2551517

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