In Silico Screening for Novel Leucine Aminopeptidase Inhibitors with 3,4-Dihydroisoquinoline Scaffold

Cancers are the leading cause of deaths worldwide. In 2018, an estimated 18.1 million new cancer cases and 9.6 million cancer-related deaths occurred globally. Several previous studies have shown that the enzyme, leucine aminopeptidase is involved in pathological conditions such as cancer. On the ba...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Joanna Ziemska, Jolanta Solecka, Małgorzata Jarończyk
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Subjects:	leucine aminopeptidase inhibitor 3,4-dihydroisoquinoline molecular docking structure-based drug design 3D-QSAR drug-likeness
Online Access:	https://www.mdpi.com/1420-3049/25/7/1753