Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity

AbstractMessenger RNA (mRNA) has become one of the most potential drugs in recent years. However, efficient and safe delivery of fragile and easily degradable mRNA is a major challenge. Appropriate delivery system (DS) determines the final effect of mRNA. Cationic lipids play a crucial and decisive...

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Bibliographic Details

Published in:	Drug Delivery
Main Authors:	Lin Wang, Huanchun Xing, Shuai Guo, Wenbin Cao, Zinan Zhang, Lijuan Huang, Sui Xin, Yuan Luo, Yongan Wang, Jun Yang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Subjects:	Liposome mRNA transfection nanocarrier lipid nanoparticle mRNA drug
Online Access:	https://www.tandfonline.com/doi/10.1080/10717544.2023.2219869