Case Report: Adult NTRK-Rearranged Spindle Cell Neoplasm: Early Tumor Shrinkage in a Case With Bone and Visceral Metastases Treated With Targeted Therapy

BackgroundNTRK (neurotrophic tyrosine receptor kinase)-rearranged spindle cell neoplasms are a new group of tumors included in the new 5th edition of the World Health Organization (WHO) classification of soft Tissue and Bone Sarcomas. These tumors are characterized by NTRK gene fusions and show a wi...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Federica Recine, Alessandro De Vita, Valentina Fausti, Federica Pieri, Alberto Bongiovanni, Eugenia Franchini, Roberto Casadei, Maria Cristina Falasconi, Devil Oboldi, Federica Matteucci, Maria Caterina Pallotti, Laura Mercatali, Nada Riva, Lorena Gurrieri, Silvia Vanni, Chiara Liverani, Giacomo Miserocchi, Chiara Spadazzi, Claudia Cocchi, Toni Ibrahim
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	NTRK-rearranged spindle cell neoplasm NTRK fusions oncogenic driver alterations targeted therapies visceral and bone involvement
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.740676/full