Maternal Under- and Over-Nutrition during Gestation Causes Islet Hypertrophy and Sex-Specific Changes to Pancreas DNA Methylation in Fetal Sheep

The mechanisms by which fetal programming predisposes offspring to reduced β-cell function later in life are poorly understood. We hypothesized that maternal under- and over-nutrition during gestation would negatively affect offspring pancreas development and alter DNA methylation patterns. Pregnant...

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Bibliographic Details

Published in:	Animals
Main Authors:	Maria Peterson, Mary Gauvin, Sambhu Pillai, Amanda Jones, Katelyn McFadden, Katelynn Cameron, Sarah Reed, Steven Zinn, Kristen Govoni
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	beta cell function fetal programming DNA methylation endocrine pancreas sheep
Online Access:	https://www.mdpi.com/2076-2615/11/9/2531