Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design

Gastroretentive bilayer tablets of calcium carbonate (CC) were developed using D-optimal mixture design. The effect of formulation factors such as levels of HPMC K100 M (X1), sodium bicarbonate (X2), and HPMC E15 LV (X3) on responses like floating lag time (R1) and release of CC at 1 h (R2) and 6 h...

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發表在:	e-Polymers
Main Authors:	Moganti Manasa, Nanjappa Shivakumar H.
格式:	Article
語言:	英语
出版:	De Gruyter 2021-01-01
主題:	calcium carbonate floating tablets gastroretentive tablets mixture design optimization
在線閱讀:	https://doi.org/10.1515/epoly-2021-0008