Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

Research and therapeutic applications using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) require robust differentiation strategies. Efforts to improve hPSC-CM differentiation have largely overlooked the role of extracellular matrix (ECM). The present study investigates the ability o...

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Bibliographic Details

Published in:	eLife
Main Authors:	Jianhua Zhang, Zachery R Gregorich, Ran Tao, Gina C Kim, Pratik A Lalit, Juliana L Carvalho, Yogananda Markandeya, Deane F Mosher, Sean P Palecek, Timothy J Kamp
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2022-06-01
Subjects:	extracellular matrix fibronectin mesoderm cardiac differentiation pluripotent stem cells integrin linked kinase
Online Access:	https://elifesciences.org/articles/69028