Effect of vasopressin V2-receptor antagonist tolvaptan on syndrome of inappropriate antidiuresis (SIAD) after transsphenoidal pituitary surgery: recovery of measured osmolality

Background: Delayed hyponatremia after pituitary surgery can be treated with the V2-receptor antagonist, oral tolvaptan. We investigated the pharmacological effect of oral tolvaptan against SIAD in patients with hyponatremia after pituitary surgery. Methods: Thirty-nine patients with pituitary adeno...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Masahiko Tosaka, Rei Yamaguchi, Yutaro Itabashi, Naoto Mukada, Haruka Tsuneoka, Kentaro Takahashi, Shunsuke Nakamura, Takahiko Nakazawa, Yuhei Yoshimoto
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Subjects:	Tolvaptan Vasopressin V2-receptor antagonist Hyponatremia Pituitary Surgery
Online Access:	http://www.sciencedirect.com/science/article/pii/S240584402202254X