Comparative safety evaluation of pentavalent (DTaP-IPV-Hib) and hexavalent (DTaP-IPV-Hib-HepB) vaccines in infants: a real-world analysis based on VAERS

BackgroundCombination vaccines simplify immunization schedules and improve compliance, making them a global priority in pediatric immunization strategies. The DTaP-IPV-Hib pentavalent vaccine has been widely adopted, and with the incorporation of the hepatitis B vaccine (HepB), the DTaP-IPV-Hib-HepB...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Zhen Wei, Bai Li, Hong-Ling Jia
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	combination vaccines safety pentavalent vaccine hexavalent vaccine disproportionality analysis multivariable logistic regression VAERS
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2025.1666509/full