Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions

Ten Eleven Translocation (TET) proteins can oxidize 5-methylcytosine to generate in sequential steps oxidized forms of cytosine: 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine. Through their catalytic activity TET proteins promote active DNA demethylation. There are three TET prote...

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書誌詳細

出版年:	Frontiers in Immunology
主要な著者:	Tarmo Äijö, Marianthi Gioulbasani, Jair Ernesto Valenzuela, Ageliki Tsagaratou
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2025-08-01
主題:	TET proteins TCR sequencing TCR diversity TCR clonality TCR oligoclonal expansion
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638500/full