Evaluating the effects of glutaraldehyde concentration and incubation time on the structural integrity of the human pericardium

BackgroundGlutaraldehyde (GA) fixation of pericardial tissue is widely used in bioprosthetic heart valves. However, how GA concentration and incubation time jointly influence structure-function relationships remains incompletely understood. This study systematically evaluates the effects of GA conce...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Sahra Tasdelen, Gianluca Dimonte, Irna Cutuk, Andreas Teuschl-Woller, Thomas Poschner, Severin Laengle, Viktoriia Tymoshenko, Barbara Messner, Thomas Augustin, Lena Hirtler, Martin Andreas
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2026-06-01
Subjects:	biomaterials cardiac surgery mechanical properties pericardium tissue processing
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2026.1746518/full