Activation of Autophagic Flux Maintains Mitochondrial Homeostasis during Cardiac Ischemia/Reperfusion Injury

Reperfusion injury after extended ischemia accounts for approximately 50% of myocardial infarct size, and there is no standard therapy. HDAC inhibition reduces infarct size and enhances cardiomyocyte autophagy and PGC1α-mediated mitochondrial biogenesis when administered at the time of reperfusion....

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Bibliographic Details

Published in:	Cells
Main Authors:	Lihao He, Yuxin Chu, Jing Yang, Jin He, Yutao Hua, Yunxi Chen, Gloria Benavides, Glenn C. Rowe, Lufang Zhou, Scott Ballinger, Victor Darley-Usmar, Martin E. Young, Sumanth D. Prabhu, Palaniappan Sethu, Yingling Zhou, Cheng Zhang, Min Xie
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Subjects:	autophagy mitochondrial biogenesis mitochondrial dynamics ROS myocardial ischemia/reperfusion injury
Online Access:	https://www.mdpi.com/2073-4409/11/13/2111