Tuning the Binding Affinity of Heme-Responsive Biosensor for Precise and Dynamic Pathway Regulation

Summary: Current challenge for dynamic pathway control in metabolic engineering is enabling the components of the artificial regulatory system to be tunable. Here, we designed and built a heme-responsive regulatory system containing a heme biosensor HrtR and CRISPRi to regulate chemicals production...

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Bibliographic Details

Published in:	iScience
Main Authors:	Jian Zhang, Zhiguo Wang, Tianyuan Su, Huanhuan Sun, Yuan Zhu, Qingsheng Qi, Qian Wang
Format:	Article
Language:	English
Published:	Elsevier 2020-05-01
Subjects:	Bioengineering Metabolic Engineering Biotechnology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004220302522