GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus

Recombinant adenovirus (rAdV) is a commonly used vector system for gene transfer. Efficient initial packaging and subsequent production of rAdV remains time-consuming and labor-intensive, possibly attributable to rAdV infection-associated oxidative stress and reactive oxygen species (ROS) production...

Full description

Bibliographic Details

Published in:	Genes and Diseases
Main Authors:	Guozhi Zhao, Piao Zhao, Yonghui Wang, Hui Zhang, Yi Zhu, Jiamin Zhong, Wulin You, Guowei Shen, Changqi Luo, Ou Mei, Xingye Wu, Jingjing Li, Yi Shu, Hongwei Wang, William Wagstaff, Hue H. Luu, Yang Bi, Lewis L. Shi, Russell R. Reid, Tong-Chuan He, Li Jiang, Wei Tang, Jiaming Fan, Ziwei Tang
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2024-11-01
Subjects:	GAPDH Gene therapy Oxidative stress Packaging cell line Reactive oxygen species Recombinant adenovirus
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304224001417