RTL551 treatment of EAE reduces CD226 and T-bet+ CD4 T cells in periphery and prevents infiltration of T-bet+ IL-17, IFN-γ producing T cells into CNS.

Recombinant T cell receptor ligands (RTLs) that target encephalitogenic T-cells can reverse clinical and histological signs of EAE, and are currently in clinical trials for treatment of multiple sclerosis. To evaluate possible regulatory mechanisms, we tested effects of RTL therapy on expression of...

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出版年:	PLoS ONE
主要な著者:	Sushmita Sinha, Lisa M Miller, Sandhya Subramanian, Gregory G Burrows, Arthur A Vandenbark, Halina Offner
フォーマット:	論文
言語:	英語
出版事項:	Public Library of Science (PLoS) 2011-01-01
オンライン･アクセス:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021868&type=printable