Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head

Abstract Purpose The objective of this study was to identify potential genes implicated in the “peri-collapse” synovium of osteonecrosis of the femoral head through coding gene sequencing and to further clarify their specific mechanisms via in vitro experiments. Methods Steroid-induced osteonecrosis...

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Bibliographic Details

Published in:	Journal of Orthopaedic Surgery and Research
Main Authors:	Han Longfei, Fang Weihua, Han Mingli, Zhuang Zhikun, He Mincong, Wei Qiushi
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Gene expression profiles Steroid-induced osteonecrosis of the femoral head Apoptosis Synovial fibroblasts Collapse
Online Access:	https://doi.org/10.1186/s13018-025-05557-x