UCK2 promotes intrahepatic cholangiocarcinoma progression and desensitizes cisplatin treatment by PI3K/AKT/mTOR/autophagic axis

Abstract Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive tumor with extremely poor prognosis due to the low resection rate, high recurrence rate and drug resistance. Uridine-cytidine kinase 2 (UCK2) is proved to promote progression and drug resistance of various carcinomas by regulatin...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Xiwen Wu, Da Chen, Muqi Li, Gehao Liang, Huizhen Ye
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-08-01
Online Access:	https://doi.org/10.1038/s41420-024-02140-x