UCK2 promotes intrahepatic cholangiocarcinoma progression and desensitizes cisplatin treatment by PI3K/AKT/mTOR/autophagic axis

Abstract Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive tumor with extremely poor prognosis due to the low resection rate, high recurrence rate and drug resistance. Uridine-cytidine kinase 2 (UCK2) is proved to promote progression and drug resistance of various carcinomas by regulatin...

Full description

Bibliographic Details
Published in:	Cell Death Discovery
Main Authors:	Xiwen Wu, Da Chen, Muqi Li, Gehao Liang, Huizhen Ye
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-08-01
Online Access:	https://doi.org/10.1038/s41420-024-02140-x

Similar Items

Dual blockage of PI3K-mTOR and FGFR induced autophagic cell death in cholangiocarcinoma cells
by: Narumon Mahaamnad, et al.
Published: (2024-05-01)

HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma
by: Zhipeng Li, et al.
Published: (2023-03-01)

Correction: HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma
by: Zhipeng Li, et al.
Published: (2024-02-01)

Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway
by: Huayuan Liu, et al.
Published: (2021-09-01)

Ibrutinib Contributes to Atrial Arrhythmia through the Autophagic Degradation of Connexins by Inhibiting the PI3K-AKT-mTOR Signaling Pathway
by: Huiyuan Qin, et al.
Published: (2024-05-01)

Roles of PI3K/AKT/mTOR Axis in Arteriovenous Fistula
by: Stefano Ratti, et al.
Published: (2022-02-01)

PI3K/AKT/mTOR pathway in Angiogenesis
by: Jayashree eKarar, et al.
Published: (2011-12-01)

The modulatory influence of Hydroxysafflor yellow A on autophagic processes in Parkinson's disease via PI3K/AKT/mTOR signaling pathway
by: Qianhua Dai, et al.
Published: (2026-06-01)

Activation of PI3K/AKT/mTOR signaling axis by UBE2S inhibits autophagy leading to cisplatin resistance in ovarian cancer
by: Mengjun Zhang, et al.
Published: (2023-12-01)

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
by: Mingyang Jiang, et al.
Published: (2025-08-01)

PI3K/Akt/mTOR inhibitors in breast cancer
by: Joycelyn JX Lee, et al.
Published: (2015-12-01)

Author Correction: Tanshinone IIA affects the malignant growth of Cholangiocarcinoma cells by inhibiting the PI3K-Akt-mTOR pathway
by: Huayuan Liu, et al.
Published: (2025-05-01)

Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
by: Songbo Xie, et al.
Published: (2014-01-01)

LDLR promotes autophagy‐mediated cisplatin resistance in ovarian cancer associated with the PI3K/AKT/mTOR signaling pathway
by: Lei Liu, et al.
Published: (2023-08-01)

TREM2 contributes to central sensitization through PI3K/Akt/mTOR-mediated autophagic dysfunction in a rat model of vestibular migraine
by: Changman Zhang, et al.
Published: (2026-03-01)

Mouse embryonic palatal mesenchymal cells maintain stemness through the PTEN-Akt-mTOR autophagic pathway
by: Lungang Shi, et al.
Published: (2019-07-01)

PI3K/AKT/mTOR-Targeted Therapy for Breast Cancer
by: Kunrui Zhu, et al.
Published: (2022-08-01)

Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma
by: Eun Jin Sun, et al.
Published: (2021-11-01)

AFF4 promotes tumor progression and cisplatin resistance by modulating the PTEN/PI3K/AKT/mTOR axis to accelerate glycolysis in lung adenocarcinoma
by: Xufeng Yao, et al.
Published: (2025-08-01)

Inhibition of PI3K/Akt/mTOR overcomes cisplatin resistance in the triple negative breast cancer cell line HCC38
by: Katharina Gohr, et al.
Published: (2017-11-01)

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells.
by: Chao Zhang, et al.
Published: (2016-01-01)

The Role of the PI3K/Akt/mTOR Axis in Head and Neck Squamous Cell Carcinoma
by: Qian Jiang, et al.
Published: (2024-07-01)

The Emerging Role and Clinical Significance of PI3K-Akt-mTOR in Rhabdomyosarcoma
by: Ilaria Versari, et al.
Published: (2025-02-01)

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases
by: Tolulope O. Omolekan, et al.
Published: (2024-09-01)

A review of photobiomodulation on PI3K/AKT/mTOR in wound healing
by: Patricia Kasowanjete, et al.
Published: (2024-02-01)

Targeting EGFR/PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma
by: Jieun Bang, et al.
Published: (2023-08-01)

PKM2 Knockdown Induces Autophagic Cell Death via AKT/mTOR Pathway in Human Prostate Cancer Cells
by: Prasanta Dey, et al.
Published: (2019-05-01)

Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis
by: Wei Huang, et al.
Published: (2024-12-01)

AURKB and PI3K/AKT/mTOR pathways converge to regulate TERT expression
by: Grace Lim, et al.
Published: (2025-08-01)

Research on the role and mechanism of the PI3K/Akt/mTOR signalling pathway in osteoporosis
by: Chuanlong Liu, et al.
Published: (2025-05-01)

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
by: Antonino Glaviano, et al.
Published: (2023-08-01)

Interaction of ncRNAs and the PI3K/AKT/mTOR pathway: Implications for osteosarcoma
by: Shao Weilin, et al.
Published: (2024-08-01)

The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases
by: Amin Iranpanah, et al.
Published: (2023-03-01)

Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention
by: Nazanin Momeni Roudsari, et al.
Published: (2021-08-01)

Cyclophosphamide Inhibits PI3K/AKT/mTOR Signaling Pathway in Mice Kidneys
by: Gulsah Albayrak, et al.
Published: (2018-12-01)

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia
by: Sophie Park, et al.
Published: (2010-05-01)

Downregulation of PI3K/AKT/mTOR Pathway in Juglone-Treated Bovine Oocytes
by: Marwa El-Sheikh, et al.
Published: (2023-01-01)

Bioactive PI3-kinase/Akt/mTOR Inhibitors in Targeted Lung Cancer Therapy
by: Somayyeh Ghareghomi, et al.
Published: (2023-01-01)

The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers
by: Elisavet Paplomata, et al.
Published: (2014-07-01)

Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway
by: Attalla Farag El-kott, et al.
Published: (2019-01-01)