Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases

Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors. High levels of D-2-hydroxyglutarate inhibit the TET family of DNA demethylases and Jumonji family of histone demethylases and cause epigenetic ch...

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Bibliographic Details

Published in:	eLife
Main Authors:	Ryan Janke, Anthony T Iavarone, Jasper Rine
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-03-01
Subjects:	Heterochromatin D-2-Hydroxyglutarate Isocitrate Dehydrogenase Oncometabolite
Online Access:	https://elifesciences.org/articles/22451