Combined inhibition of BCR-ABL1 and the proteasome as a potential novel therapeutic approach in BCR-ABL positive acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a disease of lymphoid progenitor cells with an often aggressive course and is commonly caused by the BCR-ABL fusion gene t(9;22) in adults. This fusion gene encodes a constitutively active tyrosine kinase that can be effectively inhibited by tyrosine kinase inhi...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Saskia Maletzke, Azam Salimi, Margherita Vieri, Kema Marlen Schroeder, Mirle Schemionek, Behzad Kharabi Masouleh, Tim H. Brümmendorf, Steffen Koschmieder, Iris Appelmann
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-01-01
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531817/?tool=EBI