Dioscin regulates oxidative stress and autophagy in uric acid-induced HK-2 cells through the P62-KEAP1-NRF2 signaling pathway

Abstract Objective This study aims to explore the therapeutic effects and mechanisms of dioscin on the UA-induced HK-2 cells fibrosis model by modulating oxidative stress and autophagy. Methods HK-2 cells fibrosis was constructed by UA stimulation. CCK8 was used to assess cell proliferation. Flow cy...

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Bibliographic Details

Published in:	BMC Nephrology
Main Authors:	Jiashu Feng, Weiliang Zhang, Ruiqi Liu, Ting Xiang, Xinlin Wu
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	Uric acid Dioscin P62-KEAP1-NRF2 signaling pathway Oxidative stress Autophagy
Online Access:	https://doi.org/10.1186/s12882-025-04311-z