Co‐occurring KEAP1 and TP53 mutations in lung squamous cell carcinoma induced primary resistance to thoracic radiotherapy: A case report

Abstract In lung squamous cell carcinoma, KEAP1 mutations frequently coexist with TP53 mutations. A preclinical model showed that mutations leading to the activation of the KEAP1–NRF2 pathway contribute to clinical radioresistance. However, there have been few clinical reports on the association bet...

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Bibliographic Details

Published in:	Thoracic Cancer
Main Authors:	Rumi Nishimura, Tatsuya Yoshida, Masahiro Torasawa, Tairo Kashihara, Yuichiro Ohe
Format:	Article
Language:	English
Published:	Wiley 2023-01-01
Subjects:	KEAP lung squamous cell carcinoma next‐generation sequencing thoracic radiotherapy TP53
Online Access:	https://doi.org/10.1111/1759-7714.14751