Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae

Foldback inversions, also called inverted duplications, have been observed in human genetic diseases and cancers. Here, we used a Saccharomyces cerevisiae genetic system that generates gross chromosomal rearrangements (GCRs) mediated by foldback inversions combined with whole-genome sequencing to st...

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Bibliographic Details

Published in:	eLife
Main Authors:	Bin-zhong Li, Christopher D Putnam, Richard David Kolodner
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-08-01
Subjects:	dna repair genome rearrangement translocation whole genome sequencing
Online Access:	https://elifesciences.org/articles/58223