Aromatase deficiency in transplanted bone marrow cells improves vertebral trabecular bone quantity, connectivity, and mineralization and decreases cortical porosity in murine bone marrow transplant recipients.

Estradiol is an important regulator of bone accumulation and maintenance. Circulating estrogens are primarily produced by the gonads. Aromatase, the enzyme responsible for the conversion of androgens to estrogen, is expressed by bone marrow cells (BMCs) of both hematopoietic and nonhematopoietic ori...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Katie Rubitschung, Amber Sherwood, Rasesh Kapadia, Yin Xi, Asghar Hajibeigi, Katya B Rubinow, Joseph E Zerwekh, Orhan K Öz
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2024-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0296390