Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates

Aryl acrylonitriles are an important subclass of acrylonitriles in the medicinal chemistry and pharmaceutical industry. Herein, an efficient synthesis of aryl acrylonitrile derivatives using a Palladium/NIXANTPHOS-based catalyst system was developed. This approach furnishes a variety of substituted...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Yonggang Jiang, Bijun Wang, Dongxiang Liu, Dazhen Xia, Zhengfen Liu, Liang Li, Guogang Deng, Xiaodong Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Subjects:	arylacetonitrile palladium catalysis alkenylation isomerization aryl acrylonitrile
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2022.1091566/full