PD-L1 maintains neutrophil extracellular traps release by inhibiting neutrophil autophagy in endotoxin-induced lung injury

Programmed death ligand 1 (PD-L1) is not only an important molecule in mediating tumor immune escape, but also regulates inflammation development. Here we showed that PD-L1 was upregulated on neutrophils in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS). Neutrophil speci...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Cheng-long Zhu, Jian Xie, Zhen-zhen Zhao, Peng Li, Qiang Liu, Yu Guo, Yan Meng, Xiao-jian Wan, Jin-jun Bian, Xiao-ming Deng, Jia-feng Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	ARDS PD-L1 autophagy neutrophils neutrophil extracellular traps anti-PD-L1 therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.949217/full