Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis

Abstract Esophageal cancer (EC) is a leading cause of cancer-related mortality globally, with alcohol consumption being a significant risk factor. However, the genetic and molecular mechanisms linking alcohol intake to EC remain unclear. This study utilized Mendelian randomization analysis to establ...

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Bibliographic Details

Published in:	Discover Oncology
Main Authors:	Kailin Qu, Jingyan Gu, Zhi Xu, Yixiang Hepeng, Qi Ning, Xu Wu
Format:	Article
Language:	English
Published:	Springer 2025-05-01
Subjects:	Mendelian randomization Esophageal cancer Alcohol Single-cell sequencing Bulk-RNA sequencing DLEU2
Online Access:	https://doi.org/10.1007/s12672-025-02660-7