WNK2 variants associated with familial osteoarthritis alter the chondrocyte response to hyperosmotic stress

Objective Chondrocytes of the synovial joint sense and respond to changes in osmolarity to maintain joint homeostasis. We hypothesised that an abnormal response to osmotic stress is a contributing factor to loss of joint homeostasis and the development of osteoarthritis (OA). Our goal was to identif...

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Bibliographic Details

Published in:	RMD Open
Main Authors:	Chris Stubben, Gregory J Stoddard, Michael J Jurynec, Matthew Honeggar, Shivakumar R Veerabhadraiah, Nikolas H Kazmers, David J Grunwald, Derek J Matheson, Collin Aslor, Antonio C Zelada
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2025-07-01
Online Access:	https://rmdopen.bmj.com/content/11/3/e005707.full