Xbp1 targets canonical UPRER and non-canonical pathways in separate tissues to promote longevity

Summary: Transcription factors can reprogram gene expression to promote longevity. Here, we investigate the role of Drosophila Xbp1. Xbp1 is activated by splicing of its primary transcript, Xbp1u, to generate Xbp1s, a key activator of the endoplasmic reticulum unfolded protein response (UPRER). We s...

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Bibliographic Details

Published in:	iScience
Main Authors:	Mengjia Li, Haocheng Shou, Guillermo Martínez Corrales, Tatiana Svermova, Alessandra Vieira Franco, Nazif Alic
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Biological sciences Molecular biology Molecular mechanism of gene regulation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224011842