Novel Inhibitor of Keap1-Nrf2 Protein–Protein Interaction Attenuates Osteoclastogenesis In Vitro and Prevents OVX-Induced Bone Loss In Vivo

Keap1 interacts with Nrf2 by assisting in its ubiquitination and subsequent proteolysis. By preventing ROS accumulation during RANKL-induced osteoclastogenesis, Nrf2 activation can prevent the differentiation of osteoclasts. Additionally, inhibiting the Keap1-Nrf2 PPI can be an effective strategy fo...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Zhihao Chen, Hongyuan Yao, Alessandra Marie Encarnacion, Jujin Jeong, Yunju Choi, Sangwook Park, Sunwoo Lee, Taehoon Lee
Format:	Article
Language:	English
Published:	MDPI AG 2024-07-01
Subjects:	Keap1 osteoclastogenesis Nrf2 antioxidants ROS
Online Access:	https://www.mdpi.com/2076-3921/13/7/850