Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults

Abstract Background Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific CD8+ T cells in CMV infected healthy young and middle-aged adults has not been fully charac...

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Bibliographic Details

Published in:	Immunity & Ageing
Main Authors:	Jian Lu, Guobing Chen, Arina Sorokina, Thomas Nguyen, Tonya Wallace, Cuong Nguyen, Christopher Dunn, Stephanie Wang, Samantha Ellis, Guixin Shi, Julia McKelvey, Alexei Sharov, Yu-Tsueng Liu, Jonathan Schneck, Nan-ping Weng
Format:	Article
Language:	English
Published:	BMC 2022-11-01
Subjects:	Chronic infection CD70 CMV-specific CD8+ T cells Activation Expansion
Online Access:	https://doi.org/10.1186/s12979-022-00307-7