Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast

ABSTRACT Inositol pyrophosphates 5-IP7, 1-IP7, and 1,5-IP8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP8 and 1-IP7 impact gene expression by acting as agonists of RNA 3'-processing and transcription termination. 1,5-...

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Bibliographic Details
Published in:mBio
Main Authors: Beate Schwer, Isabel Prucker, Ana M. Sanchez, Jill Babor, Henning J. Jessen, Stewart Shuman
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Subjects:
Schizosaccharomyces pombe
inositol pyrophosphates
pyrophosphatases
Online Access:https://journals.asm.org/doi/10.1128/mbio.00389-25

Internet

https://journals.asm.org/doi/10.1128/mbio.00389-25

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