Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology

Abstract Background Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disorder caused by genetic loss of dystrophin protein. Extracellular microRNAs (ex‐miRNAs) are putative, minimally invasive biomarkers of DMD. Specific ex‐miRNAs (e.g. miR‐1, miR‐133a, miR‐206, and miR‐483) are highly up...

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書誌詳細

出版年:	Journal of Cachexia, Sarcopenia and Muscle
主要な著者:	Tirsa L.E. vanWestering, Yulia Lomonosova, Anna M.L. Coenen‐Stass, Corinne A. Betts, Amarjit Bhomra, Margriet Hulsker, Lucy E. Clark, Graham McClorey, Annemieke Aartsma‐Rus, Maaike vanPutten, Matthew J.A. Wood, Thomas C. Roberts
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2020-04-01
主題:	Duchenne muscular dystrophy MicroRNA Biomarkers Dystrophin X‐chromosome inactivation Muscle turnover
オンライン･アクセス:	https://doi.org/10.1002/jcsm.12506