Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

Abstract Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression. Here, we established the in vivo utility of bazedoxifene, a steroid analog clinically approved for the treatment o...

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الحاوية / القاعدة:	EMBO Molecular Medicine
المؤلفون الرئيسيون:	Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Springer Nature 2019-03-01
الموضوعات:	colon cancer gastric cancer gp130 interleukin‐11 interleukin‐6
الوصول للمادة أونلاين:	https://doi.org/10.15252/emmm.201809539