Sevoflurane-induced regulation of NKCC1/KCC2 phosphorylation through activation of Spak/OSR1 kinase and cognitive impairment in ischemia-reperfusion injury in rats

The occurrence of excitotoxic damage caused by cerebral ischemia-reperfusion (I/R) injury is closely linked to a decrease in central inhibitory function, in which the concentration of chloride inside the cells ([Cl−]i) plays a crucial role. The outflow and inflow of [Cl−]i are controlled by KCC2 and...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Yuefeng Wang, Yuanyu Zhang, Wei Yu, Mengjuan Dong, Pingping Cheng, Ye Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Ischemia-reperfusion (I/R) NKCC1/KCC2 Rats Spak/OSR1 Sevoflurane
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024085128