RU486 mitigates Hippocampal Pathology Following Status Epilepticus

Status epilepticus induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and depression-like behavior. These observations have led...

Full description

Bibliographic Details

Published in:	Frontiers in Neurology
Main Authors:	Aynara Chavez Wulsin, James P Herman, Steve C Danzer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-11-01
Subjects:	Hippocampus Mifepristone Status Epilepticus mossy cells RU486
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00214/full