AID‐expressing epithelium is protected from oncogenic transformation by an NKG2D surveillance pathway

Abstract Activation‐induced deaminase (AID) initiates secondary antibody diversification in germinal center B cells, giving rise to higher affinity antibodies through somatic hypermutation (SHM) or to isotype‐switched antibodies through class switch recombination (CSR). SHM and CSR are triggered by...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Arantxa Pérez‐García, Pablo Pérez‐Durán, Thomas Wossning, Isora V Sernandez, Sonia M Mur, Marta Cañamero, Francisco X Real, Almudena R Ramiro
Format:	Article
Language:	English
Published:	Springer Nature 2015-08-01
Subjects:	activation‐induced deaminase cancer epithelium NKG2D pancreas
Online Access:	https://doi.org/10.15252/emmm.201505348