Mechanism of DNA unwinding by MCM8-9 in complex with HROB
Abstract HROB promotes the MCM8-9 helicase in DNA damage response. To understand how HROB activates MCM8-9, we defined their interaction interface. We showed that HROB makes important yet transient contacts with both MCM8 and MCM9, and binds the MCM8-9 heterodimer with the highest affinity. MCM8-9-H...
| Published in: | Nature Communications |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-04-01
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| Online Access: | https://doi.org/10.1038/s41467-024-47936-8 |