Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation

The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear receptor superfamily. It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein (YAP) is a potent regulator of organ size. The aim of this study is to...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu, Xiao Yang, Ruimin Wang, Jianing Tian, Frank J. Gonzalez, Min Huang, Huichang Bi
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Subjects:	Constitutive androstane receptor Nuclear receptors Hepatomegaly Liver enlargement Liver regeneration Yes-associated protein
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383520308182