PI3K/Akt inhibitor partly decreases TNF-α-induced activation of fibroblast-like synoviocytes in osteoarthritis

Abstract Background The Cadherin-11 and PI3K/Akt pathway are increasingly recognized as the potential therapeutic target of osteoarthritis (OA) synovitis. The study aimed to investigate the role of PI3K/Akt signaling pathway in the expression of Cadherin-11 and migration and invasive capacity of fib...

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Bibliographic Details
Published in:Journal of Orthopaedic Surgery and Research
Main Authors: Songyang Liu, Chenxi Cao, Yujun Zhang, Guangyu Liu, Weixia Ren, Yanqi Ye, Tiezheng Sun
Format: Article
Language:English
Published: BMC 2019-12-01
Subjects:
PI3K/Akt inhibitor
TNF-α
Cadherin-11
Osteoarthritis
Fibroblast-like synoviocytes
Online Access:https://doi.org/10.1186/s13018-019-1394-4

Internet

https://doi.org/10.1186/s13018-019-1394-4

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