Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression.

Parvoviruses are single-stranded DNA viruses that have been modified to serve as vehicles for therapeutic transgene delivery in the form of recombinant Adeno-Associated Virus (rAAV2) vectors or rodent parvovirus-derived oncolytic agents. Infection with viruses of the Parvoviridae family induces a ce...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Monnette F Summers, MegAnn K Haubold, Marcel Morgenstern, Phoenix Shepherd, Clairine I S Larsen, Ava E Bartz, Gopishankar Thirumoorthy, Robert N Kirchdoerfer, Joshua J Coon, Kavi P M Mehta, Kinjal Majumder
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-08-01
Online Access:	https://doi.org/10.1371/journal.ppat.1013142