ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte

Aim Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear. Here, we investigated the role of activating transcription factor 4 (ATF4) and HO-1 in DN-induced podocyte injury. Methods Protein expression was m...

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Bibliographic Details

Published in:	Renal Failure
Main Authors:	Shizhu Yuan, Xudong Liang, Wenfang He, Mingzhu Liang, Juan Jin, Qiang He
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Subjects:	podocyte autophagy ho-1 atf4 diabetic nephropathy
Online Access:	http://dx.doi.org/10.1080/0886022X.2021.1936040