Comprehensive clinical and genetic characterization of hyperprogressive biliary tract cancer during PD-1 blockade monotherapy: case report and literature review

Abstract Background Some genetically characterized patients show the rapid disease progression during immune checkpoint inhibitors (ICIs) monotherapy, a phenomenon known as hyperprogressive disease (HPD). Case presentation Herein we report a relevant case of biliary tract cancer (BTC) that initially...

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Bibliographic Details

Published in:	BMC Medical Genomics
Main Authors:	Kang-Xin Wang, Xu-Dong Yang, Fen Guo, Hui Sun, Yue-Yu Fang, Nan-Yuan Jiang, Xiao-Feng Chen
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Hyperprogressive disease Biliary tract cancer KRAS mutation Immunotherapy
Online Access:	https://doi.org/10.1186/s12920-025-02097-5