Microglial P2X4 receptors are essential for spinal neurons hyperexcitability and tactile allodynia in male and female neuropathic mice

Summary: In neuropathic pain, recent evidence has highlighted a sex-dependent role of the P2X4 receptor in spinal microglia in the development of tactile allodynia following nerve injury. Here, using internalization-defective P2X4mCherryIN knockin mice (P2X4KI), we demonstrate that increased cell su...

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Bibliographic Details

Published in:	iScience
Main Authors:	Damien Gilabert, Alexia Duveau, Sara Carracedo, Nathalie Linck, Adeline Langla, Rieko Muramatsu, Friedrich Koch-Nolte, François Rassendren, Thomas Grutter, Pascal Fossat, Eric Boué-Grabot, Lauriane Ulmann
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	Natural sciences Biological sciences Physiology Pathophysiology Neuroscience Behavioral neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223021879