Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

A major barrier to the clinical use of erythrocytes generated in vitro from pluripotent stem cells or cord blood progenitors is failure of these erythrocytes to express adult hemoglobin. The key regulators of globin switching KLF1 and BCL11A are absent or at a lower level than in adult cells in K562...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Kongtana Trakarnsanga, Marieangela C. Wilson, Winnie Lau, Belinda K. Singleton, Steve F. Parsons, Punthita Sakuntanaga, Ryo Kurita, Yukio Nakamura, David J. Anstee, Jan Frayne
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2014-11-01
Online Access:	https://haematologica.org/article/view/7195