Targeting the leptin receptor promotes MDA-MB-231 cells’ metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue

IntroductionLeptin, a key adipokine secreted by adipose tissue (AT), has emerged as a critical mediator linking obesity and breast cancer, both of which are major global health concerns. Elevated leptin levels are detected in the circulation and in extracellular vesicles (EVs) released by adipose ti...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Carol Costa Encarnação, Carolinne Souza Amorim, Victor Aguiar Franco, Luiz Gabriel Xavier Botelho, Ronan Christian Machado dos Santos, Isadora Ramos-Andrade, Luiz Guilherme Kraemer-Aguiar, Christina Barja-Fidalgo, João Alfredo Moraes, Mariana Renovato-Martins
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	leptin obesity adipose tissue extracellular vesicles breast cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1568524/full