GPC3: a novel mutated gene in pleuropulmonary blastoma

Abstract Background Pleuropulmonary blastoma (PPB) is a rare pediatric sarcoma often associated with DICER1 mutations. However, additional genetic factors may influence disease progression and prognosis. This study identifies a novel mutation in the GPC3 gene and evaluates its potential as a prognos...

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Bibliographic Details
Published in:Discover Oncology
Main Authors: Jiahang Zeng, Xinying Wang, Yingyi Xu, Qinglin Yang, Junzheng Peng, Fenghua Wang, Jue Tang, Dongmei Huang, Jiachi Liao, Yunyu He, Lin Huang, Jianhua Liang, Le Li, Zefeng Lin
Format: Article
Language:English
Published: Springer 2025-07-01
Subjects:
Pleuropulmonary blastoma
GPC3 mutation
Prognostic biomarker
Whole-genome sequencing
Immunohistochemistry
Pediatric sarcoma
Online Access:https://doi.org/10.1007/s12672-025-02937-x

Internet

https://doi.org/10.1007/s12672-025-02937-x

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